Ellie Kildunne will earn her 50th Red Roses cap when England face Wales in the Women's Six Nations on Saturday.
Harlequins full-back Kildunne returns to the starting XV at the Principality Stadium alongside wingers Jess Breach and Abby Dow, with head coach John Mitchell making 13 changes to the team that beat Italy 38-5 in their opening match of the tournament.
Captain Zoe Aldcroft and number eight Maddie Feaunati, player of the match against Italy, are the only players to retain their positions and are joined in the back row by Sadia Kabeya.
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The Red Roses backline sees Leicester duo Tatyana Heard and Megan Jones of Leicester Tigers form the centre partnership, with Natasha Hunt and Zoe Harrison in the half-back positions.
Bristol Bears' Lark Atkin-Davies and Sarah Bern come into the front row alongside Gloucester-Hartpury prop Mackenzie Carson, with Abbie Ward and Morwenna Talling behind them at lock.
Olympian Abi Burton is among the substitutes and is in line to make her Red Roses debut from the bench in Cardiff.
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Red Roses team to play Wales
England: 15 Ellie Kildunne, 14 Abby Dow, 13 Megan Jones, 12 Tatyana Heard, 11 Jess Breach, 10 Zoe Harrison, 9 Natasha Hunt; 1 Mackenzie Carson, 2 Lark Atkin-Davies, 3 Sarah Bern, 4 Morwenna Talling, 5 Abbie Ward, 6 Zoe Aldcroft (capt), 7 Sadia Kabeya, 8 Maddie Feaunati.
Replacements: 16 Amy Cokayne, 17 Hannah Botterman, 18 Maud Muir, 19 Rosie Galligan, 20 Abi Burton, 21 Lucy Packer, 22 Holly Aitchison, 23 Helena Rowland.
Women's Six Nations fixtures
Saturday March 22
Ireland 15-27 France
Scotland 24-21 Wales
Sunday March 23
Saturday March 29
France vs Scotland, 1pm
Wales vs England, 4.45pm
Sunday March 30
Italy vs Ireland, 3pm
Saturday April 12
France vs Wales, 12.45pm
Ireland vs England, 4.45pm
Sunday April 13
Scotland vs Italy, 3pm
Saturday April 19
Italy vs France, 1pm
England vs Scotland, 4.45pm
Sunday April 20
Wales vs Ireland, 3pm
Saturday April 26
Italy vs Wales, 12.15pm
Scotland vs Ireland, 2.30pm
England vs France, 4.45pm