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In Birmingham on Thursday, the duke celebrated the efforts of the WellChild charity, which he has supported for many years, becoming patron in 2007.
This year marks the 20th anniversary of the WellChild nurses, who help to co-ordinate care for children between home and hospital, in a project that Prince Harry helped to fund.
On the duke's visit he met Nicky Holt, one of more than 50 nurses funded by WellChild, whose specialism is working with children who need ventilation to help them breathe.
The duke chatted to some of the young patients on the wards and also some of their families.
Earlier on Thursday, a train with Invictus branding was unveiled at London's Euston Station, with the name Spirit of Invictus.
The train will run on the route to Birmingham, which will be the host next year for the games, which celebrate the achievements of injured service men and women.
A row over security arrangements meant that Prince Harry did not bring Meghan or their children Archie and Lilibet to events in London, as had been originally planned.
It is not yet known whether or not Meghan will come to the UK and appear at events in Birmingham and the Midlands later in the visit, including an Invictus event at Birmingham's National Exhibition Centre.
There has also been speculation about whether Prince Harry and his wife and children will meet King Charles, but so far no plans for a meeting have been revealed.
